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KMID : 0604220050120030061
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Korean Journal Investigative Dermatology
2005 Volume.12 No. 3 p.61 ~ p.68
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The Effect of Polyamine on the Hair in C57BL/6 Mouse
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Hwang Eun-Ju
Kim Jin-Sook
Yu Dong-Kee
Kim Kyu-Han
Cho Kwang-Hyun
Eun Hee-Chul
Kim In-Kyu
Suh Dae-Hun
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Abstract
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Polyamines(putrescine, spermidine, spermine), produced by ornithine decarboxylase(ODC), are ubiquitous molecules essential to cell proliferation and differentiation. These amines are elevated in actively proliferating cells and can protect cell from apoptosis. However, polyamines also play a role in facilitating cell death. This response might be mediated by the production of hydrogen peroxide during polyamine catabolism. In this report we wanted to investigate whether polyamines have the ability to induce an apoptosis in the hair of C57BL/6 mice. We topically applied putrescine, spermidine, spermine on the back skin with various concentrations and with various time point of application. Additionally, we studied the effect of putrescine with various duration of application. H&E stain revealed that the number of hair follicles was slight decreased in putrescine and spermine at high concentration but not in spermidine. In mice applied with putrescine, hair follicles shrank and distorted and there were sclerotic changes in dermis especially at high concentration of putrescine. The mechanism of these changes by topical polyamines were obscure because it was possible by polyamine-induced cell death, polyamine catabolism product or chemical toxicity itself. Further study will be necessary to investigate the role of polyamine in hair.
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KEYWORD
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Polyamine, Hair, Putrescine, Spermine, Spermidine
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